One Dental Billing


FDA approved subgingival conveyance gadgets containing antimicrobial meds) are embedded into periodontal pockets to suppress the pathogenic microbiota. These devices slowly release the pharmacological agents so they can stay at the planned site of activity in a therapeutic concentration for an adequate time span.



  1. Do not report D4381 to depict the utilization of Perio Protect®, D4381 reports the confined conveyance of antimicrobial specialists into the periodontal pocket. The Perio Protect® technique uses custom trays to work with the conveyance of antimicrobials to the whole upper and lower arches. Utilize Dental Code (ADA Code) D5995/D5996 to report Perio Protect® trays.


  1. Do not use D4381 to report chlorhexidine or other irrigation. See D4921 to report gingival irrigation – per quadrant.



  1. Sustained or controlled releases LDAAs (nearby conveyance antimicrobial agents) are set in profound periodontal pockets trying to decrease the bacterial load in the pocket area. Diminishing the microscopic organisms will decrease the inflammation. LDAAs come as powders, gels, or slight wafer-like chips (e.G., Atridox, Arestin, Perio Chip, and so on.). The American Academy of Periodontology’s situation on LDAAs is contained in their “Proclamation on Local Delivery of Sustained or Controlled Release Antimicrobials as Adjunctive Therapy in the Treatment of Periodontics” (May 2006): “Clinicians might consider the utilization of LDAAs in constant periodontitis patients as an assistant to SR when confined repetitive as well as leftover pocket profundity more noteworthy than or equivalent to 5mm with irritation is as yet present following traditional treatments.” The conventional therapies referred to in this statement are scaling and root planning (D4341/D4342).


  1. D4381 is reported for on a for each tooth basis. The fee for every tooth should vary by the number of sites treated. A level rate (per site) or sliding scale might be utilized to set the charge. For instance, an expense for a tooth with two locales may be $55, or with three destinations may be $75 or higher. The account ought to archive that the expense depends on number of destinations treated. Numerous payers limit the complete UCR expense to one-half of a quadrant SP reimbursement. Sometimes there is a reimbursement impediment to two or three teeth for each quadrant.


  1. Chemotherapeutic specialists might be utilized as appropriate to decrease the amount of microbial microorganisms, or to adjust the host reaction through nearby conveyance. D4381 specifies a controlled delivery vehicle for the conveyance of antimicrobial agents.



  1. Some plans don’t give advantages to nearby conveyance of antimicrobial specialists. For the most part, to fit the bill for reimbursement, patients should have moderate to serious periodontal sickness and a background marked by scaling and root arranging (SP) or momentum therapy of dynamic periodontal illness. Relative periodontal diagramming can be useful in exhibiting ordinary treatment (SP) has not been viable. Know that while a couple of dental plans pay for D4381 when set at the hour of root arranging and scaling (SP), most cutoff reimbursement for D4381 to regions that keep on draining on testing something like a month and a half following SRP treatment, and by and large at the D4910 visit.


  1. In a few cases, D4381 might be viewed as a “reclaim” code by certain payers. If osseous surgery (D4260/D4261) is started in something like a year of revealing D4341, the fee reimbursed for osseous surgery may be reduced by the amount previously reimbursed for D4381. Reimbursement for D4381 is highly variable among payers.


  1. D4381 repayment for a similar site might be denied for as long as two years following the underlying treatment. A few payers repay D4381 on a yearly premise. Repayment for D4381 is highly variable.


  1. When submitting D4381 with a pre-determination, demonstrate the time stretch expected between the SP visit and proposed D4381 treatment date. A six-week least after SRP might be required.


  1. The insured’s medical pharmacy benefit may pay for the antimicrobial agent. Contact an Arestin® representative for further additional data in regards to clinical protection charging.


  1. Report D4381 for position of FDA approved localized antimicrobial specialists like Arestin® PerioChip®, and Atridox®.The descriptor of D4381 expects that the specialist should be “FDA endorsed” – so homemade libation treatment (non FDA supported) can’t be accounted for. D4381 is an assistant to Dental Codes (ADA Codes) D4341, D4342, or D4910. D4381 is likewise an assistant to the prophylaxis (D1110) when used to treat a couple of separated pockets. Note: D4381 may not be repaid whenever put at the underlying scaling and root arranging (D4341/D4342) arrangement. The patient is generally expected to pay personal for the primary application, whenever set at the underlying scaling and root arranging (D4341/D4342) arrangement. D4381 is most frequently repaid when used at the four to multi week assessment arrangement after SRP. D4381 might be repaid whenever put at an ensuing continuous periodontal upkeep (D4910) visit when furnished related to site explicit scaling and root arranging methods performed to treat inert pockets. A few payers expect that the patient be a month and a half post SRP prior to repaying D4381. It is suggested that inclusion and restrictions be checked with the payer prior to giving D4381.



  1. The narrative should document that underlying scaling and root arranging (SP) didn’t determine every one of the pockets. Likewise notice the genuine drug, not the trademark (Minocycline HCL, not Arestin®.) Documentation like SP history, outlining at all visits, finding, loss of connection, radiographic proof of bone misfortune, draining on testing, dates of re-assessment, and so forth, with continuous periodontal diagramming is normally required. Likewise, record the ideal result of the strategy, as well as including any contributing clinical factors like diabetes, coronary illness, careful contender for hip substitution, and so on. In the event that D4381 is utilized trying to keep away from bony medical procedure, likewise demonstrate this expectation in the narrative.


  1. A story ought to constantly be submitted while revealing D4381 in relationship with a periodontal canker, for conceivable repayment. See table beneath for archiving D4381 on the ADA Dental Claim Form.


Documenting on the ADA Dental Claim Form:

Record of Services Provided

Procedure Date

Tooth Number

Procedure Code






Localized Delivery





Localized Delivery (2 sites)





Localized Delivery





Localized Delivery



Remarks: “6mm MB site of #13, 5mm DB and 7mm MB site of #14, 6mm ML site of #15 and 6mm DL site of #30. The fee listed reflects material costs and number of sites treated. Minocycline HCL micro spheres applied.”

Enclosures: Probing charts of mm/dd/yy and mm/dd/yy and radiographs.


  1. Reimbursement for D4381 frequently requires inert 5mm to 7mm pockets no less than about a month and a half after SRP, loss of connection or bone misfortune, draining on examining (BOP). This is characteristic of dynamic periodontal illness. These lethargic regions ought to be restricted to a few explicit teeth treated per quadrant. Furthermore, any rising pocket profundity readings in the wake of scaling and root arranging (SP) ought to be noted.’ “‘See appended pre-employable and post-usable periodontal outlining. ‘Be sure to document any systemic medical issues, such as diabetes, heart disease, etc.


  1. If the Arestin® is outfitted by the patient’s clinical drug store benefits, the dental specialist might charge a situation expense, detailing D4381. The position (work) charge would be less and ordinarily restricted to two teeth for every quadrant. Full documentation would should be given as framed in the narrative above.

Subscribe for News


We laid the foundation of One Dental Billing on the principle that “every dental office deserves a streamlined billing process.”

© 2018-2026 One Dental Billing | All Rights Reserved.

Contact Us

Phone: 908-357-1515

111 Town Square Pl, Suite 1203 Jersey City, NJ 07310